Compounds and compositions as protein kinase inhibitors

Details Compounds and compositions as protein kinase inhibitors Compounds and compositions as protein kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 403/14 (2006.01) A61K 31/404 (2006.01) A61K 31/4178 (2006.01) A61K 31/496 (2006.01) C07D 401/14 (2006.01) C07D 403/06 (2006.01) C07D 403/12 (2006.01) C07D 413/14 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2583737

The invention provides a novel class of compounds of Formula (see formula I) and pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the AbI, Bcr-Abl, cSrc, TPR-Met, Tie2, MET, FGFR3, Aurora, Axl, Bmx, BTK, c-kit, CHK2, FIt3, MST2, p70S6K, PDGFR, PKB, PKC, Raf, ROCK-ll, Rskl, SGK, TrkA, TrkB and TrkC kinases.

L'invention concerne une nouvelle classe de composés, des compositions renfermant ces composés et des méthodes d'utilisation desdits composés pour le traitement ou la prévention de maladies ou de troubles associés à une activité anormale ou sauvage de kinases, en particulier des maladies et des troubles en rapport avec une activation anormale des kinases Abl, Bcr-Abl, cSrc, TPR-Met, Tie2, MET, FGFR3, Aurora, Axl, Bmx, BTK, c-kit, CHK2, Flt3, MST2, p70S6K, PDGFR, PKB, PKC, Raf, ROCK-II, Rsk1, SGK, TrkA, TrkB et TrkC.

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