C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/495 (2006.01) A61K 31/53 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2617359
The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, Bcr-Abl, BMX, BTK, CHK2, b-RAF, c-RAF, CSK, c-SRC, Fes, FGFR3, Flt3, IKK.alpha. , IKK~ , JNK2.alpha. 2, Lck, Met, MKK4, MKK6, MST2, NEK2, p70S6K, PDGFR~ , PKA, PKB.alpha. , PKD2, Rsk1, SAPK2.alpha. , SAPK2~ , SAPK3, SGK, Tie2 and TrkB kinases.
L'invention concerne une nouvelle classe de composés, des compositions pharmaceutiques comprenant ces composés et des procédés d'utilisation de ces composés pour prévenir ou traiter des maladies ou des troubles associés à une activité anormale ou déréglée de kinases, en particulier des maladies ou des troubles impliquant une activation anormale des kinases Abl, Bcr-Abl, BMX, BTK, CHK2, b-RAF, c-RAF, CSK, c-SRC, Fes, FGFR3, Flt3, IKK.alpha., IKK.beta., JNK2.alpha.2, Lck, Met, MKK4, MKK6, MST2, NEK2, p70S6K, PDGFR.beta., PKA, PKB.alpha., PKD2, Rsk1, SAPK2.alpha., SAPK2.beta., SAPK3, SGK, Tie2 et TrkB.
Gray Nathanael S.
Liu Yi
Wang Xing
Xie Yongping
Zhang Guobao
Fetherstonhaugh & Co.
Irm Llc
LandOfFree
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