Compounds and compositions as protein kinase inhibitors

Details Compounds and compositions as protein kinase inhibitors Compounds and compositions as protein kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/519 (2006.01)

Patent

CA 2536535

The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, BCR-Abl, Bmx, CSK, TrkB, FGFR3, Fes, Lck, B-RAF, C-RAF, MKK6, SAPK2.alpha. and SAPK2.beta. kinases.

L'invention concerne une nouvelle classe de composés, des compositions pharmaceutiques renfermant ces composés ainsi que des procédés d'utilisation de ces composés pour traiter ou prévenir les maladies ou les troubles associés à une activité kinase anormale ou déréglée, en particulier des maladies ou des troubles qui impliquent l'activation anormale des kinases Abl, BCR-Abl, Bmx, CSK, TrkB, FGFR3, Fes, Lck, B-RAF, C-RAF, MKK6, SAPK2.alpha. et SAPK2.beta..

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