Compounds and compositions as protein kinase inhibitors

Details Compounds and compositions as protein kinase inhibitors Compounds and compositions as protein kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 495/14 (2006.01) A61K 31/437 (2006.01) C07D 471/14 (2006.01)

Patent

CA 2619049

The invention provides a novel class of compounds of formula I, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the AbI, Bcr- AbI, Aurora-A, SGK, Tie-2, Trk-B, FGFR3, c-kit, b- RAF, c-RAF, DYRK2, Fms, Fyn and PDGFRalpha and PDGFR&bgr; kinases.

La présente invention se rapporte à une nouvelle classe de composés, à des compositions pharmaceutiques comprenant de tels composés et à des procédés d~utilisation de tels composés pour traiter ou prévenir des maladies ou des troubles associés à une activité kinase anormale ou dérégulée, particulièrement les maladies ou les troubles qui impliquent une activation anormale des kinases AbI, Bcr-Abl, Aurora-A, SGK, Tie-2, Trk-B, FGFR3, c-kit, b-RAF, c-RAF, DYRK2, Fms, Fyn et PDGFR.alpha. et PDGFR.beta..

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