C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 213/74 (2006.01) C07D 239/48 (2006.01) C07D 239/95 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/12 (2006.01) C07D 403/14 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01) C07D 451/02 (2006.01) C07D 453/02 (2006.01) C07D 471/04 (2006.01) C07D 473/16 (2006.01) C07D 487/04 (2006.01) C07D 487/08 (2006.01)
Patent
CA 2671744
The invention provides novel pyrimidine and pyridine derivatives of formula (I) and pharmaceutical compositions thereof, and methods for using such compounds. For example, the pyrimidine and pyridine derivatives of the invention may be used to treat, ameliorate or prevent a condition which responds to inhibition of anaplastic lymphoma kinase (ALK) activity, focal adhesion kinase (FAK), zeta-chain-associated protein kinase 70 ZAP-70), insulin-like growth factor (IGF- 1R), or a combination thereof.
L'invention porte sur une nouvelle pyrimidine et des dérivées de pyridine, sur des compositions pharmaceutiques les contenant et sur leurs méthodes d'utilisation. La pyrimidine et lesdits dérivées peuvent servir à traiter, améliorer ou prévenir des états résultant de l'inhibition de l'activité de la kinase de lymphome anaplastique (ALK), de la kinase d'adhérence focale (FAK), de la protéine kinase 70 associée à la chaîne zêta (ZAP 70), et du facteur de croissance type insuline (IGF-1R), ou de leurs combinaisons.
Chen Bei
Jiang Tao
Jin Yunho
Lu Wenshuo
Marsilje Thomas H.
Fetherstonhaugh & Co.
Irm Llc
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