Compounds and compositions as protein kinase inhibitors

Details Compounds and compositions as protein kinase inhibitors Compounds and compositions as protein kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01) A61K 31/506 (2006.01) A61P 25/00 (2006.01) A61P 33/06 (2006.01) A61P 35/00 (2006.01) C07D 403/12 (2006.01) C07D 405/14 (2006.01) C07D 407/14 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2668190

The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to beat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of c-kit, PDGFR.alpha. and PDGFR.beta. kinases. Formula (I).

La présente invention concerne une classe innovante de composés, des compositions pharmaceutiques comprenant ces composés et des procédés d'utilisation de ces composés pour le traitement ou la prévention de maladies ou d'affections associées à une activité kinase anormale ou dérégulée, en particulier des maladies ou des affections qui mettent en jeu une activation anormale des kinases c-kit, PDGFR et PDGFR. Formule (I).

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