C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/02 (2006.01) A61K 31/519 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2626350
The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the AbI, Bcr-Abl, Aurora- A, AxI, BMX, CHK2, c-RAF, cSRC, Fes, FGFR3, Flt3, IKK.alpha., IR, JNK2.alpha.2, Lck, Met, MKK6, MST2, p70S6K, PDGFR.alpha., PKA, PKD2, ROCK-II, Ros, Rskl, SAPK2.alpha., SAPK2.beta., SAPK3 SAPK4, Syk, Tie2 and TrkB kinases.
L'invention concerne une nouvelle classe de composés, des compositions pharmaceutiques qui comprennent ces composés et des procédés d'utilisation de ces composés pour traiter ou prévenir des maladies ou des affections associés à une activité anormale ou dérégulée des kinases et en particulier les maladies ou affections associés à une activation anormale des kinases d'AbI, de Bcr-Abl, d'Aurora-A, d'AxI, de BMX, de CHK2, de c-RAF, de cSRC, de Fes, de FGFR3, de Flt3, d'IKK.alpha., d'IR, de JNK2.alpha.2, de Lck, de Met, de MKK6, de MST2, de p70S6K, de PDGFR.alpha., de PKA, de PKD2, de ROCK-II, de Ros, de Rskl, de SAPK2.alpha., de SAPK2.beta., de SAPK3, de SAPK4, de Syk, de Tie2 et de TrkB.
Gray Nathanael S.
Nagle Advait
Fetherstonhaugh & Co.
Irm Llc
The Scripps Research Institute
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