Compounds and compositions as tlr activity modulators

Details Compounds and compositions as tlr activity modulators Compounds and compositions as tlr activity modulators

C - Chemistry, Metallurgy

07

D

C07D 221/12 (2006.01) A61K 31/4375 (2006.01) A61P 37/04 (2006.01) C07D 471/04 (2006.01) C07D 471/12 (2006.01) C07D 491/056 (2006.01) C07D 491/12 (2006.01) C07D 495/04 (2006.01)

Patent

CA 2716706

The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with Toll-Like Receptors, including TLR7 and TLR8. In one aspect, the compounds are useful as adjuvants for enhancing the effectiveness of a vaccine (formula I) wherein: X3 is N; X4 is N Or CR3; X5 is -CR4=CR5.

Cette invention concerne une nouvelle classe de composés, des compositions pharmaceutiques comprenant ces composés et des méthodes dutilisation de ces composés pour traiter ou prévenir des maladies ou des affections associées avec les récepteurs TLR (Toll-Like Receptors), notamment le TLR7 et le TLR8. Dans un aspect, les composés sont utilisés comme adjuvants pour stimuler lefficacité dun vaccin (formule I) où : X3 est N; X4 est N ou CR3; X5 est -CR4=CR5.

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