Compounds and compositions for cognition-enhancement,...

C - Chemistry – Metallurgy – 07 – D

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C07D 413/04 (2006.01) A61K 31/222 (2006.01) A61K 31/4245 (2006.01) A61K 31/454 (2006.01) A61K 31/506 (2006.01) A61P 25/14 (2006.01) A61P 25/18 (2006.01) A61P 25/28 (2006.01)

Patent

CA 2754203

Muscarinic agonists, which are useful for stimulating muscarinic receptors and treating cognitive disorders, are provided. Methods of synthesizing such agonists also are provided. Also provided are compositions for enhancing cognitive function in subjects such as humans, the compositions comprising a muscarinic agonist or a pharmaceutically suitable form thereof. Also provided are methods of treating animals such as humans by administering such compositions.

L'invention concerne des agonistes muscariniques qui sont utiles pour stimuler les récepteurs muscariniques et traiter des troubles cognitifs. L'invention concerne des procédés de synthèse de tels agonistes. Elle concerne aussi des compositions destinées à améliorer la fonction cognitive chez des sujets tels que des êtres humains, ces compositions comprenant un agoniste muscarinique ou une forme pharmaceutiquement appropriée de celui-ci. L'invention concerne aussi des procédés utilisant de telles compositions pour traiter des animaux, p. ex. des être humains.

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