Compounds and compositions for the detection and treatment...

C - Chemistry – Metallurgy – 07 – D

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C07D 498/10 (2006.01) C07D 498/04 (2006.01) C07D 513/04 (2006.01) C07D 513/10 (2006.01)

Patent

CA 2718035

One aspect of the present invention relates to compounds, com-positions and methods for diagnosis and/or treatment of a subject suffering from an amyloidosis-associated pathological condition. In certain embodiments, the imaging and/or therapeutic agents of the instant invention may be administered to a subject for identification and/or treatment of amyloid deposits. A specific imaging method detects amyloid deposits by administering the imaging agent to the subject and detecting the spatial distribution of the agent. Differential accumulation of the agent is indicative of AD or an amyloidosis- associated pathological condition and can be monitored by using a PET or SPECT camera.

Un aspect de la présente invention concerne des composés, des compositions et des procédés pour le diagnostic et/ou le traitement d'un sujet souffrant d'un état pathologique associé à l'amylose. Dans certains modes de réalisation, les agents dimagerie et/ou agents thérapeutiques de la présente invention peuvent être administrés à un sujet pour l'identification et/ou le traitement de dépôts amyloïdes. Un procédé dimagerie spécifique détecte les dépôts amyloïdes en administrant l'agent d'imagerie au sujet et en détectant la répartition dans l'espace de l'agent. L'accumulation différentielle de l'agent est caractéristique de la maladie d'Alzheimer ou dun état pathologique associé à lamylose et peut être surveillée en utilisant une caméra PET (positron emission tomography) ou SPECT (single photon emission computed tomography).

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