Compounds and compositions useful for producing analgesia

C - Chemistry – Metallurgy – 07 – C

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260/489.7, 260/5

C07C 51/60 (2006.01) C07C 51/09 (2006.01)

Patent

CA 1244048

NOVEL COMPOUNDS AND COMPOSITIONS USEFUL FOR PRODUCING ANALGESIA ABSTRACT Methylenealkanamide compounds, and pharma- ceutically-acceptable salts thereof, of the formula: Image wherein X is O or S; R is straight or branched methylene sub- stituted alkane having from 11 to 23 carbon atoms; R1 is H, OH, or OCH3; R2 is OH or a short-chain ester; and wherein at least one of R1 and R2 is OH or OCH3. Compositions, useful for producing analgesia in humans or lower animals, comprise a safe and effective amount of: a methylenealkanamide, pharma- ceutically-acceptable salts thereof, or mixtures thereof; and a pharmaceutically-acceptable carrier. Preferably, these methyl- enealkanamides are N-vanillyl-methylenealkanamides. Methods of treatment, comprising administering a safe and effective amount of these methylenealkanamides, pharmaceutically-acceptable salts thereof, or mixtures thereof, include methods of parenteral, oral and topical administration.

458763

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