C - Chemistry – Metallurgy – 08 – B
Patent
C - Chemistry, Metallurgy
08
B
C08B 37/00 (2006.01) A61K 31/727 (2006.01) A61L 27/20 (2006.01) A61L 31/16 (2006.01) A61L 33/08 (2006.01) A61L 33/10 (2006.01) C08B 37/08 (2006.01) C08B 37/10 (2006.01)
Patent
CA 2484269
The invention relates to oligo- and polysaccharides containing the sugar structural element N-acylglucosamine or N-acylgalactosamine, in addition to the use thereof for producing haemocompatible surfaces and to methods for coating surfaces in a haemocompatible manner with said oligo- and polysaccharides, which constitute the common biosynthetic precursor substances of heparin, heparan sulphates and chitosan. The invention also relates to methods for producing the oligo- and/or polysaccharides, in addition to diverse application options involving haemocompatible surfaces. The invention specifically relates to the use of the oligo- and/or polysaccharides on stents involving at least one haemocompatible coating that has been applied according to the invention and that contains an anti-proliferative, anti-inflammatory and/or athrombogenic active ingredient, to methods for producing said stents and to the use of the latter for preventing restenosis.
L'invention concerne des oligosaccharides et des polysaccharides, qui contiennent le groupe fonctionnel sucre N-acylglucosamine ou N-acylgalactosamine, ainsi que leur utilisation pour la réalisation de surfaces hémocompatibles, et des procédés pour recouvrir de façon hémocompatible des surfaces avec ces oligosaccharides et/ou polysaccharides, lesquels constituent les précurseurs biosynthétiques communs de l'héparine, des héparane sulfates et du chitosan. L'invention concerne en outre des procédés de production de ces oligosaccharides et/ou polysaccharides, ainsi que diverses possibilités d'utilisation de surfaces pourvues d'un revêtement hémocompatible. L'invention concerne spécialement l'utilisation des oligosaccharides et/ou polysaccharides sur des stents, notamment dans au moins un revêtement hémocompatible appliqué selon l'invention, lequel contient un principe actif antiprolifératif, anti-inflammatoire et/ou anti-trombogénique, des procédés de production de tels stents et l'utilisation de ceux-ci pour empêcher la resténose.
Di Biase Donato
Faust Volker
Hoffmann Erika
Hoffmann Michael
Horres Roland
Goudreau Gage Dubuc
Hemoteq Ag
Hemoteq Gmbh
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