Compounds and method for the treatment of overactive bladder

Details Compounds and method for the treatment of overactive bladder Compounds and method for the treatment of overactive bladder

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) A61K 31/4545 (2006.01) A61K 45/06 (2006.01) A61P 13/10 (2006.01)

Patent

CA 2465429

NK2R binding compounds in accord with structural diagram (I) useful for the treatment or prevention of OAB or UI in mammals, particularly humans are disclosed wherein in said compounds D, A, R1, R3 and R4 are as defined in the specification. Pharmaceutically-advantageous salts of the compounds, methods of use of the compounds, either alone or in combination with other pharmacological agents, and pharmaceutical compositions useful in practicing the methods of the invention are also disclosed.

L'invention concerne des composés se liant à NK2R représentés par la formule structurale (I), utiles dans le traitement ou la prévention de la vessie hyperactive et de l'incontinence urinaire chez des mammifères, notamment chez l'être humain. Dans ces composés, D, A, R?1¿, R?3¿ et R?4¿ sont tels que définis dans le descriptif. L'invention concerne aussi des sels pharmaceutiquement avantageux des composés, des procédés d'utilisation des composés, seuls ou en combinaison avec d'autres agents pharmacologiques, ainsi que des compositions pharmaceutiques utiles pour mettre en oeuvre les procédés de l'invention.

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