C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/12 (2006.01) A61K 31/50 (2006.01) A61K 31/501 (2006.01) A61P 35/00 (2006.01) C07D 237/08 (2006.01) C07D 401/14 (2006.01)
Patent
CA 2710039
The invention relates to a compound of Formula (I) and/or a pharmaceutically-acceptable salt, hydrate, solvate, tautomer, optical isomer, E-isomer, Z-isomer, or combination thereof, wherein X is selected from S or O; R5 is selected from a substituted or unsubstituted aromatic group, a substituted or unsubstituted heteroaromatic group, or (Formula II) and the remaining substituents are described herein; and a composition comprising the thiosemicarbazone and/or the semicarbazone. The invention also relates to a method of administration of a thiocarbazone and/ or a semicarbazone; and use thereof to treat a cancer.
La présente invention concerne un composé de formule (I) : formule (I) et/ou un sel, hydrate, solvate, tautomère, isomère optique, isomère E, isomère Z, ou une combinaison de ceux-ci, pharmaceutiquement acceptables, caractérisé en ce que X est choisi parmi S ou O; R5 est choisi parmi un groupe aromatique substitué ou non substitué, un groupe hétéroaromatique substitué ou non substitué, ou (formule II) et les substituants restants sont présentement décrits; et une composition comprenant la thiosemicarbazone et/ou la semicarbazone. L'invention concerne en outre un procédé d'administration d'une thiocarbazone et/ou d'une semicarbazone; et l'utilisation de ceux-ci pour traiter un cancer.
Danter Wayne R.
Lau Cheuk Kun
Critical Outcome Technologies Inc.
Sim & Mcburney
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