Compounds and method of treatment having agonist-like...

Details Compounds and method of treatment having agonist-like... Compounds and method of treatment having agonist-like...

C - Chemistry, Metallurgy

07

D

C07D 233/54 (2006.01) A61K 31/4164 (2006.01) A61P 43/00 (2006.01) C07D 401/06 (2006.01) C07D 405/06 (2006.01) C07D 409/06 (2006.01)

Patent

CA 2441410

A compound having a structure selected from the group consisting of: in which each x is independently (1) or (2); Y is selected from the group consisting of O;S;N;-(C(R7)z)s-where each R7 IS independently as previously defined fir R1, each z is independently 1-2, and s is 1-3;CH=; -CH=CH ;or Y1CH2_where Y1 is O, N, or S; and the dotted lines are optional double bonds, with the pviso that if the ring including Y is a cyclohexane ring or a heterocyclic 5 member ring said ring is not fully unsaturated, and that if Y is O,N or S, the ring including Y contains at least one said double bond, said compound further having selective agonist activity at the .alpha.2B or .alpha.2B/.alpha.2C adrenergic receptor subtype(s) over the .alpha.2A adrenergic receptor subtype, and all pharmacologically acceptable salts, esters, stereoisomers and racemic mixtures thereof.

L'invention concerne des méthodes et des composés permettant de traiter des états comprenant la douleur, la douleur particulièrement chronique, le glaucome ou la pression intra-oculaire élevée, en entraînant des effets secondaires sédatifs et cardiovasculaires réduits. L'invention concerne en outre des méthodes de production et d'utilisation desdits composés.

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