Compounds and methods

Details Compounds and methods Compounds and methods

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A61K 31/7105 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2665202

A small nucleic acid molecule that down-regulates expression of Wrap53 gene via RNA interference (RNAi), wherein at least one strand of said small nucleic acid molecule is about 15 to about 30 nucleotides in length; and wherein at least one strand of said small nucleic acid molecule comprises a nucleotide sequence having sufficient complementarity to an RNA of said Wrap53 gene for the small nucleic acid molecule to direct cleavage of said RNA via RNA interference, for use as a medicament.

La présente invention concerne une petite molécule d'acide nucléique qui régule à la baisse l'expression du gène Wrap53 via une interférence ARN (ARNi), au moins un brin de ladite petite molécule d'acide nucléique est d'une longueur comprise entre environ 15 à environ 30 nucléotides. Au moins un brin de la petite molécule d'acide nucléique comporte une séquence nucléotidique présentant une complémentarité suffisante avec un ARN dudit gène Wrap53 pour que la petite molécule d'acide nucléique oriente un clivage dudit ARN via une interférence ARN. Ladite petite molécule d'acide nucléique destinée à être utilisée comme médicament.

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