A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/55 (2006.01) C07C 233/65 (2006.01) C07C 233/66 (2006.01) C07C 233/67 (2006.01) C07C 233/75 (2006.01) C07C 233/80 (2006.01) C07C 233/81 (2006.01) C07C 237/22 (2006.01) C07C 237/42 (2006.01) C07C 255/60 (2006.01) C07D 209/08 (2006.01) C07D 209/42 (2006.01) C07D 213/75 (2006.01) C07D 215/38 (2006.01) C07D 215/58 (2006.01) C07D 223/16 (2006.01) C07D 231/56 (2006.01) C07D 235/06 (2006.01) C07D 249/14 (2006.01) C07D 261/14 (2006.01) C07D 277/82 (2006.01) C07D 285/135 (2006.01) C07D 295/13 (2006.01) C07D 2
Patent
CA 2264942
This invention relates to 3,4-dinitrobenzamide compounds which are ligands, in particular, antagonists, of the Calcitonin Gene-Related Peptide ("CGRP") receptor. In addition, this invention relates to the treatment and prevention of disease states mediated by CGRP, including, but not limited to, headaches, especially migraines; non-insulin dependent diabetes mellitus; neurogenic inflammation; cardiovascular disorders; chronic inflammation; pain; endotoxic shock; arthritis; allergic rhinitis; allergic contact dermatitis; inflammatory skin conditions; and asthma, all in mammals, by the use of 3,4- dinitrobenzamide CGRP receptor antagonists.
Cette invention concerne des composés 3,4-dinitrobenzamide, lesquels sont des ligands, notamment des antagonistes, du récepteur du peptide lié au gène de la Calcitonine ("CGRP"). De plus, cette invention concerne le traitement et la prévention d'états pathologiques induits par CGRP, y compris, de façon non limitative les maux de tête, notamment les migraines; le diabète sucré non insulino-dépendant, l'inflammation neurogène, les troubles cardio-vasculaires, l'inflammation chronique, la douleur, le choc endotoxique, l'arthrite, les rhinites allergiques, l'eczéma de contact allergique, les états cutanés inflammatoires ainsi que l'asthme, tous chez des mammifères, par l'utilisation d'antagonistes 3,4-dinitrobenzamide du récepteur du CGRP.
Gowling Lafleur Henderson Llp
Smithkline Beecham Corporation
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