C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 59/60 (2006.01) A61K 31/192 (2006.01) A61K 31/557 (2006.01) A61P 9/12 (2006.01) A61P 11/00 (2006.01)
Patent
CA 2526534
This invention pertains generally to prostacyclin analogs and methods for their use in promoting vasodilation, inhibiting platelet aggregation and thrombus formation, stimulating thrombolysis, inhibiting cell proliferation (including vascular remodeling), providing cytoprotection, preventing atherogenesis and inducing angiogenesis. Generally, the compounds and methods of the present invention increase the oral bioavailability and circulating concentrations of treprostinil when administered orally. Compounds of the present invention have formula (I).
L'invention se rapporte d'une manière générale à des analogues de prostacycline et des procédés de leur utilisation visant ce qui suit: favoriser la vasodilatation, inhiber l'agrégation de plaquettes et la formation de thrombus, stimuler la thrombolyse, inhiber la prolifération cellulaire (y compris le remodelage vasculaire), assurer la cytoprotection, empêcher l'athérogenèse et induire l'angiogenèse. D'une manière générale, les composés et les procédés de la présente invention augmentent la biodisponibilité orale et les concentrations de circulation du treprostinil lorsque celui-ci est administré par voie orale. Les composés de la présente invention ont la formule (I).
Mottola David
Phares Ken
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
United Therapeutics Corporation
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