C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/34 (2006.01) A61K 31/7088 (2006.01) A61K 38/17 (2006.01) A61K 38/46 (2006.01) A61K 45/00 (2006.01) A61K 48/00 (2006.01) C12N 9/22 (2006.01) C12Q 1/68 (2006.01) G01N 33/573 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2510150
The present invention relates to compounds and methods for detection and treatment of carcinomas and their precursor lesions. The invention provides DNase nucleic acids and polypeptides useful for the detection and treatment of carcinomas and their precursor lesions. The invention is more specifically related to a method for detection of carcinomas and their precursor lesions comprising the detection of the level and/or the subcellular localization of one or more DNase molecules in biological samples. Furthermore the present invention provides methods for early diagnosis, prognosis and monitoring of the disease course of carcinomas and their precursor lesions as well as for the treatment of said lesions.
La présente invention concerne des composés et des méthodes de détection et de traitement de carcinomes et de leurs lésions précurseurs. Les méthodes de l'invention mettent en oeuvre des acides nucléiques d'ADNase et des polypeptides utiles pour la détection et le traitement de carcinomes et de leurs lésions précurseurs. L'invention concerne plus spécifiquement une méthode de détection de carcinomes et de leurs lésions précurseurs, qui consiste à détecter le niveau et/ou la localisation sous-cellulaire d'une ou de plusieurs molécules d'ADNase dans des prélèvements biologiques. L'invention concerne en outre des méthodes permettant d'établir un diagnostic et un pronostic précoces, et de surveiller l'évolution de carcinomes et de leurs lésions précurseurs; et des méthodes de traitement de ces lésions.
Borden Ladner Gervais Llp
Coy Johannes
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