Compounds and methods for detection of cells

Details Compounds and methods for detection of cells Compounds and methods for detection of cells

C - Chemistry, Metallurgy

07

C

C07C 309/66 (2006.01) A61K 49/00 (2006.01) A61K 51/04 (2006.01) C07C 309/73 (2006.01)

Patent

CA 2674466

The invention relates to compounds comprising an ester group for the detection in vivo of cells undergoing cell death ("dying cells") such as, for example, cells undergoing apoptosis. These compounds are selectively retained in dying cells relative to normal cells. Thus, the compounds may be used in the detection, diagnosis and treatment of clinical conditions manifested by a cell death process.

L'invention porte sur des composés comprenant un groupe ester pour la détection in vivo de cellules subissant la mort cellulaire ("cellules mourantes") comme par exemple des cellules subissant l'apoptose. Ces composés sont sélectivement retenus dans des cellules mourantes relativement à des cellules normales. Ainsi, lesdits composés peuvent être utilisés pour la détection, le diagnostic et le traitement d'états cliniques se manifestant par un processus de mort cellulaire.

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