Compounds and methods for development of ret modulators

Details Compounds and methods for development of ret modulators Compounds and methods for development of ret modulators

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) G06F 19/12 (2011.01) A61K 31/437 (2006.01) C07K 14/705 (2006.01) C07K 14/82 (2006.01) G01N 33/15 (2006.01) G01N 33/53 (2006.01) C12Q 1/48 (2006.01) C40B 30/02 (2006.01)

Patent

CA 2550361

Compounds active on Ret are described, as well as methods of using such compounds. Also described are crystal structures of Ret surrogates that were determined using X-ray crystallography. The use of such Ret surrogate crystals and strucural information can, for example, be used for identifying molecular scaffolds and for developing ligands that bind to and modulate Ret and for identifying improved ligands based on known ligands.

L'invention concerne des composés agissant activement sur Ret, ainsi que des méthodes d'utilisation de tels composés. Cette invention a aussi trait à des structures cristallines de substituts de Ret qui ont été déterminées au moyen d'une cristallographie à rayons X. L'utilisation de tels cristaux de substituts de Ret et des informations structurelles peut, par exemple, s'appliquer dans l'identification de structures d'échafaudage moléculaires, dans le développement de ligands qui se lient et modulent Ret, et dans l'identification de ligands améliorés à partir de ligands connus.

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