Compounds and methods for dlivery of prostacyclin analogs

Details Compounds and methods for dlivery of prostacyclin analogs Compounds and methods for dlivery of prostacyclin analogs

C - Chemistry, Metallurgy

07

C

C07C 59/60 (2006.01) A61K 31/192 (2006.01) A61K 31/216 (2006.01) A61P 9/12 (2006.01) A61P 11/00 (2006.01) C07C 69/712 (2006.01) C07C 235/04 (2006.01)

Patent

CA 2736406

This invention pertains generally to prostacyclin analogs and methods for their use in promoting vasodilation, inhibiting platelet aggregation and thrombus formation, stimulating thrombolysis, inhibiting cell proliferation (including vascular remodeling), providing cytoprotection, preventing atherogenesis and inducing angiogenesis. Generally, the compounds and methods of the present invention increase the oral bioavailability and circulating concentrations of treprostinil when administered orally. Compounds of the present invention have formula (I).

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