Compounds and methods for enhancing erythropoiesis

Details Compounds and methods for enhancing erythropoiesis Compounds and methods for enhancing erythropoiesis

A - Human Necessities

61

K

A61K 31/7034 (2006.01) A61P 1/00 (2006.01) A61P 1/16 (2006.01) A61P 7/06 (2006.01) A61P 9/00 (2006.01) A61P 9/10 (2006.01) A61P 11/00 (2006.01) A61P 13/12 (2006.01) A61P 17/00 (2006.01) A61P 19/02 (2006.01) A61P 19/08 (2006.01) A61P 21/00 (2006.01) A61P 25/00 (2006.01) A61P 37/08 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2747996

Compounds and methods for enhancing erythropoiesis are disclosed. The compound comprises a chemical structure of the formula (I) indicated below, in which R is a glycosyl group. In addition to having an erythropoiesis effect, the compound of the formula (I) is effective in enhancing erythropoietin formation, increasing kidney function and the expression of hepatocyte growth factor. The method includes the step of administering an effective amount of the compound of the formula (I) to a subject in need thereof and thereby enhancing erythropoiesis.

La présente invention concerne des composés et des méthodes d'amplification de l'érythropoïèse. Le composé comprend une structure chimique de formule (I) ci-après, où R représente un groupement glycosyle. En plus de son effet érythropoïétique, le composé de formule (I) agit en amplifiant la formation d'érythropoïétine, en améliorant la fonctionnalité rénale et en augmentant l'expression du facteur de croissance des hépatocytes. La méthode inclut l'étape d'administration d'une quantité active du composé de formule (I) à un sujet nécessitant un tel traitement pour amplifier l'érythropoïèse.

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