Compounds and methods for immunotherapy and diagnosis of...

A - Human Necessities – 61 – K

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A61K 39/04 (2006.01) A61K 49/00 (2006.01) C07K 1/00 (2006.01) C07K 14/35 (2006.01) C12N 15/00 (2006.01) G01N 33/53 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2337638

Compounds and methods for inducing protective immunity against tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one immunogenic portion of one or more M. tuberculosis proteins and DNA molecules encoding such polypeptides. Such compounds may be formulated into vaccines and/or pharmaceutical compositions for immunization against M. tuberculosis infection, or may be used for the diagnosis of tuberculosis.

L'invention concerne des composés et des méthodes destinés à induire une immunité protectrice contre la tuberculose. Les composés de cette invention renferment des polypeptides contenant au moins une partie immunogène d'une ou plusieurs protéines de M. tuberculosis et molécules d'ADN codant pour ces polypeptides. Ces composés peuvent entrer dans la composition de vaccins et/ou de compositions pharmaceutiques pour une immunisation contre toute infection à M. tuberculosis, ou être utilisés pour diagnostiquer la tuberculose.

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