C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/407 (2006.01) A61K 31/4155 (2006.01) A61K 31/427 (2006.01) A61K 31/4353 (2006.01) A61P 31/14 (2006.01)
Patent
CA 2624333
Macrocyclic compounds having the structures described herein are useful for inhibiting replication of the hepatitis C virus (HCV). In preferred embodiments, the compounds are active against both the NS3 protease and the NS3 helicase of HCV.
Des composés macrocycliques dont les structures sont décrites dans la présente invention peuvent être employés dans l'inhibition de la réplication du virus de l'hépatite C (VHC). Dans des modes de réalisation préférés, les composés sont actifs à la fois contre la protéase NS3 et contre la hélicase NS3 du VHC.
Andrews Steven
Beigelman Leonid
Blatt Lawrence M.
Haas Julia
Seiwert Scott D.
Array Biopharma Inc.
Intermune Inc.
Smart & Biggar
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