Compounds and methods for inhibiting selectin-mediated function

Details Compounds and methods for inhibiting selectin-mediated function Compounds and methods for inhibiting selectin-mediated function

C - Chemistry, Metallurgy

07

H

C07H 15/252 (2006.01) A61K 31/70 (2006.01) A61P 37/00 (2006.01) C07H 13/10 (2006.01)

Patent

CA 2486106

Compounds and methods are provided for modulating in vitro and in vivo processes mediated by selectin binding. More specifically, selectin modulators and their use are described, wherein the selectin modulators that modulate (e.g., inhibit or enhance) a selectin-mediated function comprise a class of compounds termed BASAs (Benzyl Amino Sulfonic Acids, which include a portion or analogue thereof) linked to a carbohydrate or glycomimetic.

L'invention concerne des composés et des procédés de modulation in vitro et in vivo des processus induits par la liaison des sélectines. Plus particulièrement, l'invention concerne des modulateurs de sélectines et leur utilisation. Les modulateurs de sélectines qui modulent (c.-à-d., inhibent ou stimulent) une fonction induite par les sélectines, comprennent une classe de composés appelés BASA (Benzyl Amino Sulfonic Acids, qui contiennent une partie ou un analogue correspondant) qui sont liés à un glucide ou à un glycomimétique.

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