C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 5/06 (2006.01) A61K 38/08 (2006.01) C07K 14/705 (2006.01) C07K 14/78 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2286291
Modulating agents for inhibiting an interaction between .alpha.-catenin and .beta.-catenin are provided. The modulating agents comprise one or more of: (a) a .beta.-catenin HAV motif; (b) a peptide analogue or mimetic of a .beta.- catenin HAV motif; or (c) an antibody or antigen-binding fragment thereof that specifically binds to a .beta.-catenin HAV motif. Methods for using such modulating agents for inhibiting cadherin-mediated cell adhesion in a variety of contexts are also provided.
L'invention concerne des agents modulateurs permettant d'inhiber une interaction entre l'.alpha.-caténine et la .beta.-caténine. Ces agents modulateurs contiennent (a) un ou plusieurs motifs HAV de la .beta.-caténine; (b) un ou plusieurs analogues peptidiques ou composés peptidomimétiques du motif HAV d'une .beta.-caténine; ou (c) un ou plusieurs anticorps ou fragments de fixation de l'antigène de ce motif qui se fixent en particulier sur un motif HAV de la .beta.-caténine. L'invention se rapporte également à des procédés d'utilisation de ces agents modulateurs, procédés visant à inhiber l'adhérence intercellulaire due à la cadhérine, et ce, dans une pluralité de contextes.
Blaschuk Orest W.
Gour Barbara J.
Gowling Lafleur Henderson Llp
University Mcgill
LandOfFree
Compounds and methods for inhibiting the interaction between... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Compounds and methods for inhibiting the interaction between..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compounds and methods for inhibiting the interaction between... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-2018568