C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) C07K 14/775 (2006.01) C12N 15/85 (2006.01)
Patent
CA 2405870
This invention provides methods of lowering cholesterol, delaying the onset of atherosclerosis, or treating atherosclerosis in a mammal without inducing hypertriglyceridemia. These methods involve administering to or expressing in a mammal, an apoE polypeptide or nucleic acid that, when administered to or expressed in a mammal, lowers the total serum cholesterol level without inducing hypertriglyceridemia.
L'invention concerne des méthodes permettant de réduire les taux de cholestérol, de retarder le début de l'athérosclérose ou de traiter l'athérosclérose chez un mammifère sans induire une hypertriglycéridémie. Ces méthodes consistent à administrer à un mammifère ou à exprimer chez un mammifère, un polypeptide ou un acide nucléique apoE qui, lorsqu'il est administré à un mammifère ou exprimé chez un mammifère, réduit le taux total de cholestérol sérique sans induire une hypertriglycéridémie.
Kypreos Kyriakos E.
Zannis Vassilis I.
Kos Life Sciences Inc.
Kos Pharmaceuticals Inc.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Trustees Of Boston University
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