A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/17 (2006.01) C12N 5/0784 (2010.01) A61K 39/02 (2006.01) A61K 39/12 (2006.01) A61K 39/35 (2006.01) A61K 39/39 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C07K 14/435 (2006.01) C12N 15/12 (2006.01)
Patent
CA 2755983
The present invention relates to the identification of proteins which bind the dendritic cell marker known as Clec9A. The present invention provides new compounds for targeting therapeutic agents such as antigens to dendritic cells. Also provided are methods of modulating a humoral and/or T cell mediated immune response to the antigen, methods of delivery of a cytotoxic agent to dendritic cells thereof involved in diseased states, methods of modulating the uptake and/or clearance of cells with a disrupted cell membrane, cells infected with a pathogen, dying cells or dead cells, or a portion thereof, and methods of modulating antigen recognition, processing and/or presentation, as well as immune responses to material derived from cells with a disrupted cell membrane, cells infected with a pathogen, dying cells or dead cells, or a portion thereof.
L'invention porte: sur l'identification de protéines se fixant au marqueur de cellules dendritiques dit Clec9A; sur de nouveaux composés de ciblage d'agents thérapeutiques tels que des antigènes de cellules dendritiques; sur des méthodes de modulation d'une réponse immunitaire, humorale et/ou médiée par une cellule T, à un antigène; sur une méthode de délivrance d'un agent cytotoxique à des cellules dendritiques impliquées dans des états morbides; sur des méthodes de modulation du captage ou et/ou de la clairance de cellules à membrane rompue, de cellules infectées par un pathogène, de cellules mourantes ou mortes, ou de leur parties; sur une méthode de modulation de la reconnaissance du traitement et/ou de la présentation, d'antigènes, ainsi que des réponses immunitaires à des matériaux dérivant de cellules à membrane rompue, de cellules infectées par un pathogène, de cellules mourantes ou mortes, ou de leur parties
Caminschi Irina
Cowman Alan
Huang David Ching Siang
Lahoud Mireille Hanna
Nicola Nicos Anthony
Mbm Intellectual Property Law Llp
The Walter And Eliza Hall Institute Of Medical Research
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