Compounds and methods for modulating bacterial functions

Details Compounds and methods for modulating bacterial functions Compounds and methods for modulating bacterial functions

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) G01N 33/554 (2006.01) G01N 33/566 (2006.01) G01N 33/567 (2006.01)

Patent

CA 2411512

There is provided a method of reducing biofilm formation by biofilm-forming bacterial cell such as E. coli, Salmonella, or Klebsiella cells. CsrA activity levels in the cell may be modulated to impact biofilm formation and glycogen metabolism. CsrA levels may be modulated by modulating the expression of csrB RNA and UvrY and Bar A gene products. By increasing levels of csrB, BarA or SdiA in a bacterial cell or increasing the rate of UvrY phosphorylation, one can increase the levels of active UvrY in the cell. There is also provided a modulator of CsrA activity in a bacteria comprising a nucleotide sequence containing the sequence element CAGGAUG.

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