C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/705 (2006.01) A61K 47/48 (2006.01) C07K 7/06 (2006.01) C07K 7/64 (2006.01) G01N 33/566 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2333928
Modulating agents and methods for enhancing or inhibiting cadherin-mediated functions are provided. The modulating agents comprise at least an HAV binding motif, an analogue or peptidomimetic thereof, or an antibody or fragment thereof that specifically binds to such a motif. Modulating agents may additionally comprise one or more cell adhesion recognition sequences recognized by cadherins and/or other adhesion molecules. Such modulating agents may, but need not, be linked to a targeting agent, drug and/or support material.
Cette invention a trait à des agents de modulation et aux techniques afférentes renforçant ou inhibant des fonctions liés à la cadhérine. Ces agents de modulation comportent au moins un motif de reconnaissance d'adhésion à HAV (His-Ala-Val), un analogue ou un peptidomimétique de celui-ci ou un anticorps ou un fragment de celui-ci se liant de manière spécifique à ce motif. Les agents de modulation peuvent, de surcroît, comporter une ou plusieurs séquences de reconnaissance d'adhésion cellulaire reconnues par des cadhérines et/ou d'autres molécules d'adhésion. Ils peuvent, sans pour autant y être contraints, être liés à un agent de ciblage, à un médicament et/ou à un matériau support.
Blaschuk Orest W.
Doherty Patrick
Gour Barbara J.
Adherex Technologies Inc.
Gowling Lafleur Henderson Llp
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