Compounds and methods for modulating claudin-mediated functions

Details Compounds and methods for modulating claudin-mediated functions Compounds and methods for modulating claudin-mediated functions

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61P 17/02 (2006.01) A61P 35/00 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 5/10 (2006.01) C12N 15/63 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2349158

Methods for using modulating agents to enhance or inhibit claudin-mediated cell adhesion in a variety of in vivo and in vitro contexts are provided. Within certain embodiments, the modulating agents may be used to increase blood/brain barrier permeability. The modulating agents comprise at least one claudin cell adhesion recognition sequence or an antibody or fragment thereof that specifically binds the claudin cell adhesion recognition sequence. Modulating agents may additionally comprise one or more cell adhesion recognition sequences recognized by other adhesion molecules. Such modulating agents may, but need not, be linked to a targeting agent, drug and/or support material.

L'invention concerne des méthodes d'utilisation d'agents de modulation permettant de favoriser ou d'inhiber l'adhérence cellulaire induite par les claudines dans divers contextes in vivo et in vitro. Dans certains modes de réalisation, ces agents de modulation peuvent être utilisés pour accroitre la perméabilité de la barrière hémato-encéphalique. Ces agents de modulation comprennent au moins une séquence de reconnaissance de l'adhéence cellulaire induite par les claudines. Les agents de modulation peuvent comprendre, en outre, une ou plusieurs séquences de reconnaissance de l'adhérence cellulaire reconnues par d'autres molécules d'adhésion. Ces agents de modulation peuvent éventuellement être liés à un agent de ciblage, un médicament et/ou une matière de support.

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