C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 307/32 (2006.01) A61K 31/341 (2006.01) A61P 31/00 (2006.01)
Patent
CA 2596480
The present invention provides compositions and methods for modulating the communication and virulence of quorum sensing bacteria. In various exemplary embodiments, the invention provides a combinatorial library of quorum sensing compounds including synthetic analogs of naturally occurring and non-naturally occurring acyl-homoserine lactone (AHL) analogs, and methods of synthesizing and using these compounds.
La présente invention concerne des compositions et procédés de modulation de la communication et de la virulence de bactéries de mesure de quorum. Dans divers modes de réalisation, l'invention fournit une bibliothèque combinatoire de composés de mesure de quorum contenant des analogues synthétiques d'analogues de la acyl-homosérine lactone (AHL) d'origine naturelle et non naturelle. L'invention concerne également des procédés de synthèse et d'utilisation de ces composés.
Blackwell Helen E.
Geske Grant D.
Wezeman Rachel J.
Goudreau Gage Dubuc
Wisconsin Alumni Research Foundation
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