Compounds and methods for modulating endothelial cell adhesion

Details Compounds and methods for modulating endothelial cell adhesion Compounds and methods for modulating endothelial cell adhesion

C - Chemistry, Metallurgy

07

K

C07K 7/00 (2006.01) C07K 14/705 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2405476

Cyclic peptides comprising a cadherin cell adhesion recognition sequence HAV, and compositions comprising such cyclic peptides, are provided. Methods for using such peptides for modulating cadherin-mediated endothelial cell adhesion in a variety of contexts are also provided.

L'invention concerne des peptides cycliques comprenant une séquence HAV de reconnaissance de l'adhésion cellulaire de la cadhérine et des compositions renfermant de tels peptides cycliques. L'invention concerne également des procédés d'utilisation de ces peptides permettant de moduler l'adhésion des cellules endothéliales dans une variété de contextes.

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