Compounds and methods for modulating tissue permeability

Details Compounds and methods for modulating tissue permeability Compounds and methods for modulating tissue permeability

C - Chemistry, Metallurgy

07

K

C07K 14/47 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) C07K 14/705 (2006.01) C07K 16/18 (2006.01) C07K 16/28 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2351624

Methods for using modulating agents to enhance or inhibit occludin-mediated cell adhesion in a variety of in vivo and in vitro contexts are provided. Within certain embodiments, the modulating agents may be used to increase vasopermeability. The modulating agents comprise at least one occludin cell adhesion recognition sequence or an antibody or fragment thereof that specifically binds the occludin cell adhesion recognition sequence. Modulating agents may additionally comprise one or more cell adhesion recognition sequences recognized by other adhesion molecules. Such modulating agents may, but need not, be linked to a targeting agent, drug and/or support material.

La présente invention se rapporte à des procédés d'utilisation d'agents modulants dans le but de renforcer ou d'inhiber l'adhésion cellulaire induite par les occludines dans divers contextes in vivo et in vitro. Dans certaines réalisations, les agents modulants peuvent servir à accroître la vasoperméabilité. Ces agents modulants comprennent au moins une séquence de reconnaissance de l'adhésion cellulaire induite par les occludines ou un anticorps ou un fragment d'anticorps qui se lie de manière spécifique à la séquence de reconnaissance de l'adhésion cellulaire induite par les occludines. Les agents modulants peuvent en outre comporter une ou plusieurs séquences de reconnaissance de l'adhésion cellulaire reconnues par d'autres molécules d'adhésion. Ces agents modulants peuvent, non nécessairement, être liés à un agent de ciblage, à un médicament et/ou à une matière de support.

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