C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 45/00 (2006.01) C07K 1/00 (2006.01) C07K 1/107 (2006.01) C07K 1/14 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12P 21/00 (2006.01) C12Q 1/42 (2006.01) C12Q 1/48 (2006.01)
Patent
CA 2373814
Novel forms of mutant BAD polypeptides or fragments thereof having amino acid substitutions for serine-155 are provided along with their encoding polynucleotides. Also disclosed are methods for preparation of the mutant BAD polypeptides, methods for screening candidate compounds and drugs for activity that promotes cell survival or apoptosis, methods for screening candidate compounds and drugs for phosphatase activity capable of dephosphorylating BAD, methods for screening candidate compounds and drugs for kinase activity capable of phosphorylating BAD, methods for screening candidate compounds and drugs for activity that promotes phosphorylation of BAD, anti-BAD antibodies, and methods for inhibiting and inducing apoptosis.
L'invention concerne des nouvelles formes de polypeptides BAD ou de fragments de ces polypeptides comprenant des substitutions d'acide aminé à la sérine-155, ainsi que leurs polynucléotides codants. L'invention concerne également des méthodes de préparation de polypeptides BAD mutants, des méthodes de criblage de composés et de médicaments candidats destinés à favoriser la survie cellulaire ou l'apoptose, des méthodes de criblage de composés et de médicaments candidats destinés à exercer une activité de phosphatase permettant de déphosphoryler les BAD, des méthodes de criblage de composés et de médicaments candidats destinés à exercer une activité de kinase permettant de phosphoryler les BAD, des méthodes de criblage de composés et de médicaments candidats destinés à promouvoir la phosphorylation des BAD, des anticorps anti-BAD et des méthodes destinées à inhiber et à induire l'apoptose.
Apoptosis Technology Inc.
Gowling Lafleur Henderson Llp
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