C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 233/66 (2006.01) A61K 31/4164 (2006.01) A61K 31/417 (2006.01) A61K 31/4174 (2006.01) A61K 31/4178 (2006.01) A61K 31/423 (2006.01) A61K 31/428 (2006.01) A61P 31/04 (2006.01) C07D 233/54 (2006.01) C07D 233/64 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01)
Patent
CA 2453396
The present invention relates to compounds according to the formula (I): Where RA is a C1-C10 substituted or unsubstituted linear, branch-chained or cyclic alkyl or alkenyl group or a phenyl group according to the formula (II): RB is a C1-C10 substituted or unsubstituted linear, branch-chained or cyclic alkyl or alkenyl group or a phenyl group of the formula (III): R1, R2 , R3, R4, R5, R6, R7, R8, R9 and R10 are each independently selected from H, C1- C10(preferably a C1-C4)alkyl or alkenyl group, CF3, F, Cl, Br, I, CN, NO2, NH2, NHR, NRR, COR (acyl group), OR (hydroxyl or ether group), CO2R (carboxylic acid or ester group ), or COSR (thioester group) where R is H or a C1-C10(preferably a C1-C4)alkyl or alkenyl group, an unsubstituted or substituted aryl (preferably, phenyl) or heterocycle group, or a (IV) group, where R3 is H, a C1-C10 (preferably a C1-C4) alkyl, alkenyl, ether or a thioether group; and R11 and R12 are independently selected from H or a C1-C3 alkyl or alkenyl group, or a pharmaceutically acceptable salt thereof and methods for treating infections caused by protozoal, fungal and/or bacterial agents such as Trypanosoma cruzi, Mycobacterium spp., Leishmania spp., Cryptococcus spp., Aspergillus spp., Histoplasma spp., Candida spp. especially Candida albicans, Pneumocystis carinii, Trichophyton spp., Microsporum spp., Malassezia spp., Rhizopus spp., Pseudallescheria spp., Blastomyces dermatitidis and Coccidiodes spp., among others.
La présente invention concerne des composés de formule (I): où R?A¿ représente un groupe alkyle ou alcényle ou un groupe phényle cyclique ou à chaîne ramifiée, linéaire, substitué ou non en C¿1?-C¿10? selon la formule (II): R?B¿ représente un groupe alkyle ou alcényle ou un groupe phényle cyclique ou à chaîne ramifiée, linéaire, substitué ou non en C¿1?-C¿10 ?de formule (III): R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, R?6¿, R?7¿, R?8¿, R?9¿ et R?10¿ sont chacun indépendamment sélectionnés dans H, un groupe alkyle ou alcényle en C¿1?-C¿10? (de préférence en C¿1?-C¿4?), CF¿3?, F, Cl, Br, I, CN, NO¿2?, NH¿2?, NHR, NRR, COR (groupe acyle), OR (groupe hydroxyle ou éther), CO¿2?R (groupe acide carboxylique ou ester), ou COSR (groupe thioester) où R représente H ou un groupe alkyle ou alcényle en C¿1?-C¿10? (de préference en C¿1?-C¿4?), un groupe hétérocycle ou aryle (de préférence phényle) substitué ou non.
Buckner Frederick S.
Gelb Michael
Hamilton Andrew D.
Lockman Jeffrey
Ohkanda Junko
Cassan Maclean
University Of Washington
Yale University
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