Compounds and methods for the modulation of toll-like...

A - Human Necessities – 61 – K

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A61K 31/00 (2006.01)

Patent

CA 2666766

The present invention relates to compositions and methods for use in the treatment of conditions such as septicaemia and septic shock. The invention further provides compositions and methods for the suppression Toll-like Receptor 4 mediated activation of the immune system. The invention further provides screening assays to identify compounds which have utility in the foregoing compositions and methods.

La présente invention concerne des compositions et des procédés destinés à être utilisés dans le traitement d'états telles que la septicémie ou le choc septique. L'invention concerne en outre des compositions et des procédés pour la suppression de l'activation du système immunitaire à médiation par le récepteur 4 de type Toll. L'invention concerne enfin des dosages de criblage pour identifier des composés utilites dans les compositions et les procédés mentionnés ici.

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