C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 1/00 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01) A61K 39/02 (2006.01) A61K 39/08 (2006.01) C07K 14/32 (2006.01)
Patent
CA 2407443
The invention provides mutant forms of pore-forming toxins. These mutant toxins may be used in vaccines for the prevention of bacterial infection. Additionally, dominant negative mutants may be administered as therapeutics for the treatment of bacterial infection.
La présente invention concerne des formes mutantes de toxines porogènes. Ces toxines mutantes conviennent en préparations vaccinales destinées à la prévention d'infections bactériennes. En outre, une administration thérapeutique de mutants négatifs dominants permet le traitement d'une infection bactérienne.
Collier R. John
Sellman Bret R.
President And Fellows Of Harvard College
Smart & Biggar
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