A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/7036 (2006.01) A61K 9/12 (2006.01) A61K 9/72 (2006.01) A61K 31/045 (2006.01) A61K 31/13 (2006.01) A61K 31/155 (2006.01) A61K 31/185 (2006.01) A61K 31/198 (2006.01) A61K 31/66 (2006.01) A61K 31/70 (2006.01) A61K 33/00 (2006.01) A61P 11/00 (2006.01)
Patent
CA 2356637
Chronic obstructive airway diseases are treated by administering an osmotically active compound such as a salt, sugar, sugar alcohol, or organic osmolyte to the afflicted airway surface. The compound may be administered as a liquid or dry powder aerosol formulation. Diseases that can be treated by the method include cystic fibrosis, chronic bronchitis, and ciliary dyskinesia. The formulations of the invention can also be used in conjunction with other active agents such as bronchodilators, sodium channel blockers, antibiotics, enzymes, or purinoceptor agonists on airway surfaces.
On traite les maladies obstructives chroniques des voies respiratoires par administration d'un composé osmotiquement actif, tel qu'un sel, un sucre, un alcool de sucre, ou osmolyte organique sur la surface des voies respiratoires. Ce composé peut être administré sous forme d'une formulation d'aérosol en poudre sèche ou liquide. Les maladies pouvant être traitées par cette technique comprennent la mucovicidose, la bronchite chronique et la dyskinésie ciliaire. Les formulations de l'invention peuvent également être utilisées avec d'autres agents actifs, tels que des bronchodilateurs, des agents bloquants de canal de sodium, des antibiotiques, des enzymes, ou des agonistes du purinorécepteur, sur les surfaces des voies respiratoires.
Sim & Mcburney
The University Of North Carolina At Chapel Hill
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