A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/14 (2006.01) A61P 17/06 (2006.01) A61P 19/02 (2006.01) A61P 25/00 (2006.01) A61P 37/06 (2006.01)
Patent
CA 2747951
The present invention provides a method and composition for the treatment and prevention of an autoimmune disease such a multiple sclerosis which is mediated by autoreactive T cells. The administration of a NOD-1 agonist is shown to mediate an anti-inflammatory immune response. NOD-1 agonists suitable for use in the methods and compositions of the invention include diaminopimelic acid (DAP)-containing muropeptide compounds such as Tri-DAP and M-TriDAP.
Cette invention concerne une méthode et une composition utilisées dans le traitement et la prévention d'une maladie auto-immune, comme la sclérose en plaques qui est associée avec des lymphocytes T réagissant contre le propre organisme du sujet. L'administration d'un agoniste Nod1 s'avère associée avec une réponse immunitaire anti-inflammatoire. Les muropeptides renfermant de l'acide diaminopimélique (DAP), comme les composés Tri-DAP et M-TriDAP, comptent parmi les agonistes Nod1 appropriés pour être utilisés dans les méthodes et les compositions de l'invention.
Higgins Sarah
Mills Kingston
Gowling Lafleur Henderson Llp
Near Dublin The Provost Fellows And Scholars Of The College Of The Holy And
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