C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 409/12 (2006.01) A61K 31/381 (2006.01) A61K 31/404 (2006.01) A61P 19/02 (2006.01) A61P 21/00 (2006.01) A61P 29/00 (2006.01)
Patent
CA 2747957
The present invention relates generally to alkyne containing pharmaceutical agents, and in particular, to phenylethynyl-thiophene based metalloprotease inhibitor compounds. More particularly, the present invention provides a new class of MMP inhibiting compounds that exhibit increased potency, metabolic stability and/or reduced toxicity in relation to currently known MMP inhibitors for the treatment of pain and other diseases such as cancer. Additionally, the present invention relates to methods for treating pain in a patient comprising administering to the patient a pain-reducing effective amount of a present compound.
La présente invention concerne de manière générale des agents pharmaceutiques contenant des alkynes, en particulier, des composés inhibiteurs de métalloprotéase à base de phényléthynyl-thiophène. Plus particulièrement, la présente invention concerne une nouvelle classe de composés inhibant MMP qui présentent une efficacité accrue, une stabilité métabolique et/ou une toxicité réduite par rapport aux inhibiteurs de MMP actuellement connus pour le traitement de la douleur et d'autres maladies, comme le cancer. En outre, la présente invention concerne des procédés de traitement de la douleur chez un patient comprenant l'administration au patient d'une quantité efficace pour réduire la douleur d'un présent composé.
Aquilus Pharmaceuticals Inc
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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