C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 473/00 (2006.01) A61K 31/403 (2006.01) A61K 31/4152 (2006.01) A61K 31/4166 (2006.01) A61K 31/421 (2006.01) A61K 31/425 (2006.01) A61K 31/52 (2006.01) A61P 11/00 (2006.01) A61P 35/00 (2006.01) C07C 49/248 (2006.01) C07D 209/86 (2006.01) C07D 231/12 (2006.01) C07D 233/54 (2006.01) C07D 233/70 (2006.01) C07D 261/08 (2006.01) C07D 263/32 (2006.01) C07D 277/24 (2006.01) C07D 311/30 (2006.01)
Patent
CA 2669503
Methods for therapy of cystic fibrosis and other conditions such as cancer are provided. The methods comprise one or more agents capable of increasing thiol-containing compound transport via a transporter system (i.e., ABC transporters such as MDR-1 or MRP-2) in cells. Other embodiments include the use of agents to modulate transport of thiol-containing compounds within the cell. Therapeutic methods involve the administration of such agents to a patient afflicted with cystic fibrosis, cancer and/or another condition responsive to stimulation of thiol-containing compound transport.
La présente invention a trait à des procédés pour le traitement de la mucoviscidose et d'autres conditions telles que le cancer. Les procédés comprennent un ou des agents capables d'accroître le transport de composé contenant du thiol via un système transporteur (c'est à dire, des transporteurs ABC tels que MDR-1 ou MRP-2) dans des cellules. D'autres modes de réalisation comprennent l'utilisation d'agents pour la modulation de composés contenant du thiol au sein de la cellule. Des procédés thérapeutiques comprennent l'administration de tels agents chez un patient atteint de mucoviscidose, de cancer et/ou d'autre condition sensible à la stimulation de transport de composé contenant du thiol.
Day Brian J.
Kachadourian Remy
National Jewish Medical And Research Center
Smart & Biggar
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