C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 213/16 (2006.01) A61K 31/44 (2006.01) A61K 31/4427 (2006.01) C07D 213/22 (2006.01) C07D 401/04 (2006.01) C07D 401/10 (2006.01) C07D 405/10 (2006.01) C07D 409/04 (2006.01) C07D 471/04 (2006.01)
Patent
CA 2726588
Disclosed are compounds and methods for treating inflammatory and fibrotic disorders, including methods of modulating a stress activated protein kinase (SAPK) system with an active compound, wherein the active compound exhibits low potency for inhibition of the p38 MAPK; and wherein the contacting is conducted at a SAPK-modulating concentration that is at a low percentage inhibitory concentration for inhibition of the p38 MAPK by the compound. Also disclosed are derivatives and analogs of pirfenidone, useful for modulating a stress activated protein kinase (SAPK) system.
L'invention porte sur des composés et sur des procédés destinés à traiter des troubles inflammatoires et fibrotiques, comprenant des procédés consistant à moduler un système de protéine-kinase activée par le stress (SAPK) à l'aide d'un composé actif, le composé actif présentant une faible puissance d'inhibition de la MAPK p38 ; et la mise en contact étant menée à une concentration de modulation de la SAPK dont la concentration inhibitrice est à faible pourcentage pour l'inhibition de la MAPK p38 par le composé. L'invention porte également sur des dérivés et des analogues de la pirfenidone, utiles pour moduler un système de protéine kinase activé par le stress (SAPK).
Beigelman Leonid
Bianchi Ivana
Hu Tao
Kossen Karl
Raveglia Luca Francesco Mario
Intermune Inc.
Smart & Biggar
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