A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/155 (2006.01) A61K 31/196 (2006.01) A61K 31/5375 (2006.01)
Patent
CA 2329709
Compounds, compositions and methods are disclosed for treating mitochondria- associated diseases, such as cancer, psoriasis, stroke, Alzheimer's Disease and diabetes. The compounds of this invention have structure (I), including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein Ar and L are as defined herein. The methods of this invention are directed to treating a mitochondria-associated disease by administering to a warm-blooded animal in need thereof an effective amount of a compound of structure (I), typically in the form of a pharmaceutical composition.
L'invention concerne des composés, compositions et méthodes de traitement de maladies liées aux mitochondries telles que le cancer, le psoriasis, les accidents vasculaires cérébraux, la maladie d'Alzheimer et le diabète. Les composés de la présente invention possèdent la structure (I), y compris leurs stéréoisomères, promédicaments et sels acceptables du point de vue pharmaceutique, Ar et L étant comme définis ci-après. Les méthodes selon la présente invention sont destinées au traitement d'une maladie liée aux mitochondries par administration à un homéotherme en présentant le besoin, d'une quantité effective d'un composé de la structure (I), en général sous forme de composition pharmaceutique.
Davis Robert E.
Ghosh Soumitra
Gowling Lafleur Henderson Llp
Mitokor
LandOfFree
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