C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 209/10 (2006.01) A61K 31/136 (2006.01) A61K 31/192 (2006.01) A61K 31/343 (2006.01) A61K 31/357 (2006.01) A61K 31/404 (2006.01) A61K 31/4709 (2006.01) A61P 25/00 (2006.01) C07C 65/11 (2006.01) C07C 211/55 (2006.01) C07D 307/80 (2006.01) C07D 319/18 (2006.01) C07D 401/06 (2006.01) C07D 405/04 (2006.01) C07D 409/04 (2006.01)
Patent
CA 2668744
The invention is directed to compounds and methods for treating protein folder disorders. In certain embodiments the invention provides compounds and methods for treating neurodegenerative diseases such as Alzheimer's disease, tauopathy, cerebral amyloid angiopathy, Lewy body disease, dementia, Huntington's disease and prion-based spongiform encelopathy. The invention further provides compounds, methods and pharmaceutical compositions for inhibiting tau protein, A.beta. protein or .alpha.-synuclein protein aggregation.
L'invention porte sur des composés et des procédés pour traiter des troubles de repliement de protéine. Dans certains modes de réalisation, l'invention propose des composés et des procédés pour traiter des maladies neurodégénératives telles que la maladie d'Alzheimer, la tauopathie, l'angiopathie amyloïde cérébrale, la maladie à corps de Lewy, la démence, la maladie de Huntington et l'encéphalite spongiforme à base de prions. L'invention propose en outre des composés, des procédés et des compositions pharmaceutiques pour inhiber l'agrégation de la protéine tau, de la protéine Ab ou de la protéine a-synucléïne.
Carter Michael D.
Gao Fuye
Jacobo Sheila Marie H.
Lu Erhu
Weaver Donald F.
Lyon Angela
Queen's University At Kingston
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