C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/31 (2006.01) A61K 31/70 (2006.01) A61K 35/74 (2006.01) A61K 39/04 (2006.01) A61K 39/39 (2006.01) A61K 48/00 (2006.01) A61K 49/00 (2006.01) C07K 14/35 (2006.01) C07K 16/12 (2006.01) C07K 19/00 (2006.01) G01N 33/569 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2263885
The present invention provides polypeptides comprising an immunogenic portion of a M. vaccae protein and DNA molecules encoding such polypeptides, together with methods for their use in the diagnosis and treatment of mycobacterial infection. Methods for enhancing the immune response to an antigen including administration of M. vaccae culture filtrate or delipidated M. vaccae cells are also provided.
Cette invention concerne des polypeptides qui comprennent une portion immunogène d'une protéine M. vaccae, ainsi que des molécules d'ADN qui codent ces polypeptides. Cette invention concerne également des procédés d'utilisation de ces éléments dans le diagnostic et le traitement d'infections mycobactériennes. Cette invention concerne enfin des procédés permettant d'accroître la réponse immune vers un antigène, lesquels consistent à administrer un filtrât de culture de M. vaccae ou des cellules de M. vaccae délipidées.
Hiyama Jun
Prestidge Ross L.
Scott Linda M.
Skinner Margot A.
Tan Paul
Genesis Research & Development Corporation Limited
Smart & Biggar
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