A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/28 (2006.01) A61K 31/315 (2006.01) A61K 31/505 (2006.01) C07D 239/545 (2006.01) C07D 239/60 (2006.01) C07D 403/12 (2006.01) C07D 495/04 (2006.01)
Patent
CA 2321715
The present invention relates to a novel method for the treatment of neoplasia, including cancer and other diseases and conditions in humans and mammals. More particularly, in preferred aspects, the present invention provides a method for the use of a novel class of chemical agents, the 3H-1,2- Dithiolo[4,3-d]pyrimidin-5,7-diones and 4H-1,3-Dithiino[5,4-d]pyrimidin-8-one- 7S-oxides and the respective nucleosides and nucleotides, for the treatment of both neoplasia, drug sensitive and drug-resistant breast, colon, ovarian and lung cancer, among others, hyperproliferative cell growth, chronic inflammatory diseases and viral and other microbial infections.
La présente invention concerne une nouvelle méthode de traitement de la néoplasie, y compris du cancer, ainsi que d'autres maladies et états pathologiques chez l'homme et les mammifères. Plus particulièrement, dans des aspects préférés, la présente invention concerne une méthode d'utilisation d'une nouvelle classe d'agents chimiques, les 3H-1,2-Dithiolo[4,3-d]pyrimidin-5,7-diones et les 4H-1,32-Dithiino[5,4-d]pyrimidin-8-one-7S-oxydes ainsi que les nucléosides et nucléotides respectifs, destinés au traitement de la néoplasie, des cancers, pharmacosensibles et pharmacorésistants, du sein, du colon, de l'ovaire et du poumon entre autres, de la croissance cellulaire hyperproliférante, de maladies inflammatoires chroniques ainsi que d'infections virales et d'autres infections microbiennes.
Bardos Thomas J.
Dunn Joseph A.
Kung Hank F.
Cassan Maclean
The Research Foundation Of The State University Of New York
Therex Technologies Inc.
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