A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/513 (2006.01) A61K 31/19 (2006.01) A61K 31/215 (2006.01) A61K 31/395 (2006.01) A61K 38/22 (2006.01) A61K 45/06 (2006.01) A61P 3/06 (2006.01) A61P 3/10 (2006.01) A61P 9/00 (2006.01) A61P 29/00 (2006.01) C12N 9/99 (2006.01) C12N 5/06 (2006.01) C12N 5/08 (2006.01)
Patent
CA 2583947
Novel compounds, compositions comprising compounds, and methods for methods for preparing and using compounds are described herein. Methods of treating or ameliorating various conditions, including insulin resistance, pancreatic beta cell apoptosis, obesity, pro~thrombotic conditions, myocardial infarction, hypertension, dyslipidemia, manifestations of Syndrome X, congestive heart failure, inflammatory disease of the cardiovascular system, atherosclerosis, sepsis, type 1 diabetes, liver damage, and cachexia, by administering compounds described herein. Compounds presented herein may be used to modulate serine palmitoyl transferase activity.
L'invention porte sur de nouveaux composés, compositions et procédés de préparation et d'utilisation de ces composés. L'invention porte sur des méthodes de traitement ou d'amélioration de différents états pathologiques, y compris la résistance insulinique, l'apoptose pancréatique de la cellule bêta, l'obésité, les affections trhombotiques, les infarctus du myocarde, l'hypertension, la dyslipidémie, les manifestations de Syndrome X, d'insuffisance cardiaque congestive, de maladie inflammatoire du système cardiovasculaire, l'athérosclérose, le sepsis, les diabètes de type 1, l'atteinte hépatique et la cachexie, par l'administration desdits composés. Les composés décrits dans l'invention peuvent être utilisés pour moduler l'activité de la sérine palmitoyl transférase.
Ben-Oliel Susan M.
Forbes Medi-Tech (research) Inc.
Nestor John
LandOfFree
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