Compounds and methods of use

Details Compounds and methods of use Compounds and methods of use

C - Chemistry, Metallurgy

07

D

C07D 417/14 (2006.01) A61K 31/395 (2006.01) A61K 31/4709 (2006.01) A61K 31/496 (2006.01) A61K 31/519 (2006.01) A61K 31/5377 (2006.01) C07D 413/14 (2006.01) C07D 417/12 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2747161

In one aspect, the present invention provides for a compound of Formula (I) in which, the variables X1, X2a,' X2b, X2c, R1, B, L, E, A and the subscript n are as defined herein. In another aspect, the present invention provides for pharmaceutical compositions comprising compounds of Formula (I) as well as methods for using compounds of Formula (I) for the treatment of diseases and conditions (e.g., cancer, thrombocythemia, etc) characterized by the expression or over-expression of Bc1-2 anti-apoptotic proteins, e.g., of anti-apoptotic Bc1-x L proteins.

La présente invention concerne, dans un aspect, un composé de formule (1). Dans ladite formule (I), les variables X1, X2a, X2b, X2c, R1, B, L, E, A et l'indice inférieur n sont tels que définis ici. Dans un autre aspect, la présente invention concerne des compositions pharmaceutiques comprenant des composés de formule (I), ainsi que des méthodes d'utilisation de composés de formule (I) dans le traitement de maladies et d'états (par exemple le cancer, la thrombocytémie etc.) caractérisés par l'expression ou la surexpression de protéines anti-apoptotiques Bcl-2, par exemple de protéines anti-apoptotiques Bcl-xL.

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